Structural and biochemical studies on folate-dependent tRNA methyltransferase (TrmFO)

H. Nishimasu, R. Ishitani, K. Yamashita, C. Iwashita, A. Hirata, H. Hori, and O. Nureki,
“Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase.”
Proc. Natl. Acad. Sci. USA 106, 8180-8185 (2009)

R. Yamagami, K. Yamashita, H. Nishimasu, C. Tomikawa, A. Ochi, C. Iwashita, A. Hirata, R. Ishitani, O. Nureki, and H. Hori,
“The tRNA recognition mechanism of folate/FAD-dependent tRNA methyltransferase (TrmFO).”
J. Biol. Chem. 287, 42480-42494 (2012)

Our paper was selected as a  Research Highlight in A-IMBN Research from Nature Publishing Group.
“The Japanese group succeed the structural determination of  TrmFO, which is the important target protein of drug design for control of infectious bacteria.”

Structure of TrmFO